2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N3995S
    5β-Dihydrocortisol-d6
    5β-Dihydrocortisol-d6 is the deuterium labeled 5β-Dihydrocortisol. 5β-Dihydrocortisol, a metabolite of Cortisol, is a potential mineralocorticoid. 5β-Dihydrocortisol can potentiate glucocorticoid activity in raising the intraocular pressure. 5β-Dihydrocortisol causes breast cancer cell apoptosis[1][2][3][4][5].
    5β-Dihydrocortisol-d<sub>6</sub>
  • HY-143990S
    Modafinil EP impurity B-d5
    Modafinil EP impurity B-d5 is the deuterium labeled Modafinil EP impurity B[1].
    Modafinil EP impurity B-d<sub>5</sub>
  • HY-B2124R
    10,11-Dihydrocarbamazepine (Standard)
    10,11-Dihydrocarbamazepine (Standard) is the analytical standard of 10,11-Dihydrocarbamazepine. This product is intended for research and analytical applications. 10,11-Dihydrocarbamazepine is the active metabolite of Oxcarbazepine. 10,11-Dihydrocarbamazepine also is an intermediate. Oxcarbazepine is rapidly and almost completely converted to 10,11-Dihydrocarbamazepine with probable Anticonvulsant efficacy.
    10,11-Dihydrocarbamazepine (Standard)
  • HY-17026A
    Gemcitabine triphosphate
    Gemcitabine triphosphate (dFdCTP) is one of the two nucleoside metabolites of Gemcitabine (HY-17026) in cells. The other is active diphosphate (dFdDTP). Gemcitabine triphosphate can be used as a standard in radio-labeled probe imaging studies, to identify tumors sensitive to Gemcitabine, and to evaluate Gemcitabine uptake and retention by cells.
    Gemcitabine triphosphate
  • HY-151930
    8′-Hydroxy ABA
    8′-Hydroxy ABA (8'-OH-ABA) is a principal catabolite of abscisic acid (ABA). 8′-Hydroxy ABA has hormonal activity and leads to increased oil synthesis. 8′-Hydroxy ABA is a labile compound.
    8′-Hydroxy ABA
  • HY-B2150S
    4-Hydroxyantipyrine-d3
    4-Hydroxyantipyrine-d3 is the deuterium labeled 4-Hydroxyantipyrine. 4-Hydroxyantipyrine is the major metabolite of Antipyrine, can be as a biodistribution promoter. 4-Hydroxyantipyrine can increase distribution of concentration ratio of Antipyrine in the brain[1][2][3].
    4-Hydroxyantipyrine-d<sub>3</sub>
  • HY-Z9063
    1-epi-Regadenoson
    1-epi-Regadenoson is an αisomer impurity of Regadenoson which is a highly selective adenosine A2A receptor agonist.
    1-epi-Regadenoson
  • HY-G0008
    O-Desmethyl Mebeverine alcohol
    O-Desmethyl Mebeverine alcohol is a metabolite of Mebeverine, which is a potent α1 repector inhibitor, causing relaxation of the gastrointestinal tract.
    O-Desmethyl Mebeverine alcohol
  • HY-143956S
    Fluorofenidone impurity 1-d3
    Fluorofenidone impurity 1-d3 is the deuterium labeled Fluorofenidone impurity 1[1].
    Fluorofenidone impurity 1-d<sub>3</sub>
  • HY-131251
    Cetirizine 3-chloro impurity
    Cetirizine 3-chloro impurity is an impurity of Cetirizine 3-chloro.
    Cetirizine 3-chloro impurity
  • HY-153043
    DM-CO-(CH2)5-SMe
    DM-CO-(CH2)5-SMe is an anticancer agent derived from antibody-drug conjugates (ADC) metabolite with cytotoxicity to H1703, H1975, COLO704 and Colo720E cells.
    DM-CO-(CH2)5-SMe
  • HY-101407R
    Nicotinamide N-oxide (Standard)
    Nicotinamide N-oxide (Standard) is the analytical standard of Nicotinamide N-oxide. This product is intended for research and analytical applications. Nicotinamide N-oxide, an in vivo nicotinamide metabolite, is a potent, and selective antagonist of the CXCR2 receptor.
    Nicotinamide N-oxide (Standard)
  • HY-112057
    Pseudoerythromycin A enol ether
    Pseudoerythromycin A enol ether (LY267108) is a degradation product of Erythromycin. Pseudoerythromycin A enol ether has no significant antimicrobial activity.
    Pseudoerythromycin A enol ether
  • HY-W009713S
    3,4,5-Trimethoxyphenylacetic acid-d2
    3,4,5-Trimethoxyphenylacetic acid-d2 is the deuterium labeled 3,4,5-Trimethoxyphenylacetic acid[1]. 3,4,5-Trimethoxyphenylacetic acid is a metabolite of Mescaline[2].
    3,4,5-Trimethoxyphenylacetic acid-d<sub>2</sub>
  • HY-78847
    2R,4S-Sacubitril
    2R,4S-Sacubitril is the impurity of Sacubitril. Sacubitril is approved by the Food and agent Administration for use in combination with valsartan for the treatment of patients with heart failure.
    2R,4S-Sacubitril
  • HY-12769S
    Mebeverine acid-d5
    Mebeverine acid-d5 is the deuterium labeled Mebeverine Acid; Mebeverine Acid is a metabolite of Mebeverine, that is an antispasmodic.
    Mebeverine acid-d<sub>5</sub>
  • HY-133779
    Gefitinib impurity 5
    Gefitinib impurity 5 is the impurity of Gefitinib. Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity.
    Gefitinib impurity 5
  • HY-135408
    Trimetazidine-N-oxide
    Trimetazidine-N-oxide is the major active metabolite of Trimetazidine. Trimetazidine is a selective long chain 3-ketoyl coenzyme A thiolase inhibitor with an IC50 of 75 nM. Trimetazidine is an effective antianginal agent, has anti-oxidant, anti-inflammatory, antinociceptive and gastroprotective properties.
    Trimetazidine-N-oxide
  • HY-113157
    Estrone 3-glucuronide
    Estrone 3-glucuronide is deuterium labeled Estrone 3-glucuronide. Estrone 3-glucuronide, the dominant metabolite of estradiol, is determined to be the urinary marker for prediction of the fertile window.
    Estrone 3-glucuronide
  • HY-100660A
    Cetirizine Impurity B dihydrochloride
    Cetirizine Impurity B dihydrochloride is an impurity of Cetirizine dihydrochloride. Cetirizine, a second-generation antihistamine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response.
    Cetirizine Impurity B dihydrochloride
Cat. No. Product Name / Synonyms Application Reactivity